← The FormularyLong gameResveratrol
Also known as Trans-resveratrol, Japanese knotweed extractThe red wine molecule, minus the red wine and minus the promise.
Resveratrol got famous on a study about yeast and a story about French people drinking wine, and it has spent the two decades since failing to live up to both. That is not a scandal — it is what a molecule looks like when it gets tested properly. The dose here is real and the source is standardised to 98%, so if you want it, this is a defensible way to take it. But we are not selling you the wine story.
A polyphenol produced by plants under stress, sourced commercially from Japanese knotweed root rather than grapes.
Plants make it as a defence compound. In cells it interacts with signalling proteins involved in stress response, which is the thread the longevity interest hangs on. Human bioavailability is low and short-lived, which is a large part of why results have been so inconsistent.
It is one of the most-trialled natural compounds of the last twenty years. The trials have not converged on a claim.
Someone who wants it at a disclosed dose alongside NAD+ and quercetin. Not for anyone on anticoagulants without a doctor's word.
150 mg daily with food.
Nothing you can feel.
Grade C. Enormous trial volume, no authorised health claim; European assessments were negative. Safety is good at these doses, with the antiplatelet caution the one that matters.
Read the labelAffects platelet activity — relevant with blood thinners and before surgery. Also inhibits drug-clearing liver enzymes.
Evidence grades describe how well an ingredient is studied — A well-supported, C emerging — not a promise of results. Educational, not medical advice. Doses are typical ranges; follow the label on the product.