A red onion cut in half, showing tight purple concentric rings. ← The FormularyLong game

Quercetin

Also known as Quercetin dihydrate
CEVIDENCE

The flavonoid in every onion and every longevity stack.

The honest take
Quercetin has been studied for decades across inflammation, immunity, allergy and exercise, and the honest summary is that nothing has stuck hard enough to authorise. European regulators assessed the claims and rejected them. It is in this formula because it is a standard companion to NAD+ in the longevity literature, not because we can tell you what it will do for you.
What it is
A plant pigment found in onions, apples and capers, extracted here from Japanese pagoda tree flower buds.
How it works
Flavonoids like quercetin donate electrons to unstable molecules, which is the mechanism behind every antioxidant story you have read. Mechanism is not outcome, and the gap between the two is where most supplement marketing lives.
What it does
It behaves as an antioxidant in a test tube. What it does in a person, at this dose, is not settled enough to claim.
Who it's for
Anyone taking it as part of a cellular formula rather than on its own merits.
How to use it
250 mg daily, with food. Absorption is poor on an empty stomach.
What to expect
Nothing perceptible.
The research
Grade C. Extensive preclinical work, inconsistent human trials, no authorised claim. The rejection was on evidence, not safety.

Read the labelInterferes with the liver enzymes and transport proteins that move many prescription drugs — at supplemental doses, drug levels can shift in either direction. Check with a pharmacist.

Evidence grades describe how well an ingredient is studied — A well-supported, C emerging — not a promise of results. Educational, not medical advice. Doses are typical ranges; follow the label on the product.