A ripe tomato cut in half, showing wet red flesh and seeds. ← The FormularyAfter hours

GABA

Also known as Gamma-aminobutyric acid
CEVIDENCE

Your brain's brake pedal, sold in a form that may not reach it.

The honest take
This is the same problem NAD+ has. The molecule matters enormously inside you, and swallowing it is not obviously how you get more of it where it counts — GABA crosses the blood-brain barrier poorly. There is some evidence for effects via the gut, and there is a lot of marketing that skips the question entirely. We publish the dose and leave the argument visible.
What it is
The main calming neurotransmitter in your nervous system, sold as a supplement.
How it works
Inside the brain it is the primary inhibitory transmitter. Oral GABA's route is likely indirect, through gut receptors, if it works at all.
What it does
In the brain, it dampens signalling. Whether a capsule of it gets there is the open question.
Who it's for
Someone taking it as part of a blend rather than expecting it to carry the night.
How to use it
100 mg with a nightly formula.
What to expect
Little to nothing you can identify.
The research
Grade C. No approved claim. The blood-brain barrier question is unresolved and honest suppliers say so.

Read the labelAdditive with sedatives.

Evidence grades describe how well an ingredient is studied — A well-supported, C emerging — not a promise of results. Educational, not medical advice. Doses are typical ranges; follow the label on the product.